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Medication review and deprescribingThe increase in life expectancy and the growing availability of effective drugs for the management of chronic diseases are leading to an increase in the number of patients, suffering of multimorbidity, in polypharmacotherapy (regular intake of at least five...
In 2019, Italy registered approximately 65,000 spontaneous reports of suspected adverse reactions (ADR), of which around 58,000 were from drugs and 7,000 from vaccines, showing an increasing trend compared to the previous year.With the arrival of the COVID-19 pandemic, spontaneous reporting...
In the form of questions and answers the topic of vertigo in hypothyroid subjects is discussed, with particular reference to the possibility that it is an adverse drug reaction. Or maybe not?Can the appearance of vertigo in a patient undergoing therapy with levothyroxine be an adverse event due to...
Declared a pandemic by the World Health Organization in mid-March 2020, by 3 May 2020 SARS-CoV-21 had more than 3,356,000 confirmed cases and about 238,700 official deaths.2 The priority of health authorities is to limit the spread of the virus by avoiding overcrowding of hospitals to provide the...
According to the European Centre for Disease Prevention and Control, since 31 December 2019 to 8 May 2020 the SARS-CoV-2 pandemic led to more than 3.8 million infections and 269,068 deaths.1 There are conflicting assumptions about the possible adverse or protective effects of antihypertensive drugs...
Indications for medical useTetrahydrocannabinol (THC) and cannabidiol (CBD) are the main active substances of cannabis sativa and among the pharmacological targets have both cannabinoid receptors (CB1 and CB2), the peptide receptor related to the calcitonin gene, the ligand dependent ion channels...
Pathological gambling is attracting increasing attention for high prevalence, involving 0.4-2.2% of the Italian population.1 In the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), pathological gambling is among substance use and addiction related disorders and is defined as “...
Vitamin D is commonly referred to as a group of hormone function secosteroids, of which the metabolically active form is 1,25-OH.1 Vitamin D is one of the drugs that has undergone the largest increase in prescription in recent years in Italy, rising from 6.2% in 2013 to 12.6% in 2017.2 The...
A widely used class of antibioticsQuinolones and fluoroquinolones are broad-spectrum synthetic antimicrobials that are highly effective in treating a wide range of infections. Although these drugs represent a class of antibiotics of considerable medical importance, their use as a first-line...
The MEREAFAPS project (Epidemiological Monitoring of Adverse Drug Reactions and Events in Emergency Room) was launched in Lombardy in 2006. The rationale is simple: the vast majority of adverse drug reactions that occur at home take the patient to the emergency room, where doctors and nurses,...

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