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Drugs & Pregnancy
Fertility therapies: at what risks?
Focus Farmacovigilanza 2014;80(1):6
Infertility strikes 10-20% of couples in the Western countries.1 An increasing number of couples resort to medically assisted procreation techniques (intrauterine insemination, pharmacological induction of ovulation, in vitro fertilization with embryo transfer and intracytoplasmic sperm injection...
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Phytovigilance & Supplements
Safety of natural products for airways
Focus Farmacovigilanza 2013;79(11):7
Asthma is an inflammatory disease with recurrent exacerbations. Asthma exacerbations are associated to increased inflammation of the airways; in predisposed subjects, exacerbation can be caused by respiratory infections or allergen exposition. In case of asthma, complementary or alternative...
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Drugs & Children
Biliary and renal lithiasis by ceftriaxone
Focus Farmacovigilanza 2013;78(9):6
The ARNO Children Observatory Report of 2011 states that more than 30% of antibiotic treatments in paediatric age consist of cephalosporins.1 Among cephalosporins, ceftriaxone prescriptions have grown more than 75% from 2001 to 2008.2 This third generation cephalosporin, however, is no risk-free:...
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Drugs & Pregnancy
Antihypertensive drugs and pregnancy: an update
Focus Farmacovigilanza 2013;76(5):6
About 1-5% of women develop hypertensive disorders in pregnancy and some of them are treated with antihypertensive drugs.1 Gestational hypertension increases the risk of preeclampsia1 and has been associated to negative outcomes in pregnancy, like spontaneous abortion, intrauterine growth...
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Drugs & Elderly
Drug-induced falls
Focus Farmacovigilanza 2013;77(7):6
Falls represent a common and complex geriatric pathology profile.1 About 30% of elderly patients living in community fall at least once per year and half of them has frequent falls.1-2 Percentages are higher for more advanced age group and for institutionalised subjects.3 Falls and their...
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Phytovigilance & Supplements
An autoimmune syndrome induced by lipoic acid
Focus Farmacovigilanza 2013;75(3):6
In order to understand and evaluate the potential risks associated with natural products, Italy since 2002 has activated a surveillance system for adverse reactions to these products, which is coordinated by Istituto Superiore della Sanità (ISS).1 At present the database contains 850 reports of...
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Drugs & Children
Fever and pain in children between paracetamol and ibuprofen
Focus Farmacovigilanza 2013;74(1):6
Paracetamol and ibuprofen are the only antipyretic drugs recommended for pediatric age. Their administration is indicated when fever causes discomfort to the child. A recent meta-analysis showed that discontinued usage of these drugs cannot prevent fever convulsions.[1] Their usage is indicated...
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Drugs & Elderly
Warfarin and elderly patients: a challenging combination
Focus Farmacovigilanza 2012;73(11):6
Atrial fibrillation (AF) incidence increases according to patient age. Oral anticoagulant therapy with vitamin K antagonists, like warfarin, reduces stroke risk in AF patients, including elderly.[1,2] The INR (International Normalized Ratio) normal range for atrial fibrillation lays between 2 and...
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